Article
Variants of estrogen-related genes and breast cancer risk in European and African American women.
Endocrine-related cancer - 1 Jan 2014
Quan Lei, Hong Chi-Chen, Zirpoli Gary, Roberts Michelle R, Khoury Thaer, Sucheston-Campbell Lara E, Bovbjerg Dana H, Jandorf Lina, Pawlish Karen, Ciupak Gregory, Davis Warren, Bandera Elisa V, Ambrosone Christine B, Yao Song
Abstract excerpt
It has been observed previously that compared with women of European ancestry (EA), those of African ancestry (AA) are more likely to develop estrogen receptor (ER)-negative breast cancer, although the mechanisms have not been elucidated. We tested the associations between breast cancer risk and a targeted set of 20 genes known to be involved in estrogen synthesis, metabolism, and response and potential...
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