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Article

Association of estrogen receptor alpha polymorphisms with breast cancer risk in older Caucasian women.

International journal of cancer - 10 Oct 2005

Modugno Francesmary, Zmuda Joseph M, Potter Douglas, Cai Chao, Ziv Elad, Cummings Steven R, Stone Katie L, Morin Phillip A, Greene Deborah, Cauley Jane A

Abstract excerpt

Estrogens exert their effect on the breast through the estrogen receptor. We prospectively investigated breast cancer risk associated with 2 polymorphic sites in the estrogen receptor alpha gene (ESR1). A total of 4,248 Caucasian women from the Study of Osteoporotic Fractures were genotyped for the -401 T/C and -354 A/G polymorphisms in ESR1. Cox proportional hazards models were used to estimate hazard ratios...

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Identifiers

PMID: 15856463
DOI: 10.1002/ijc.21105

Genes

ESR1

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