Article
Oestrogen receptor alpha gene haplotype and postmenopausal breast cancer risk: a case control study.
Breast cancer research : BCR - 1 Jan 2004
Wedrén Sara, Lovmar Lovisa, Humphreys Keith, Magnusson Cecilia, Melhus Håkan, Syvänen Ann-Christine, Kindmark Andreas, Landegren Ulf, Fermér Maria Lagerström, Stiger Fredrik, Persson Ingemar, Baron John, Weiderpass Elisabete
Abstract excerpt
INTRODUCTION: Oestrogen receptor alpha, which mediates the effect of oestrogen in target tissues, is genetically polymorphic. Because breast cancer development is dependent on oestrogenic influence, we have investigated whether polymorphisms in the oestrogen receptor alpha gene (ESR1) are associated with breast cancer risk. METHODS: We genotyped breast cancer cases and age-matched population controls for one...
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