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Article

Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer.

Breast cancer research and treatment - 1 Nov 2005

Maguire Paula, Margolin Sara, Skoglund Johanna, Sun Xiao-Feng, Gustafsson Jan-Ake, Børresen-Dale Anne-Lise, Lindblom Annika

Abstract excerpt

Estrogen is involved in both normal mammary development and in breast carcinogenesis. A family history of disease and exposure to estrogen are major risk factors for developing breast cancer. Estrogen exerts its biological effects through binding to the estrogen receptors, estrogen receptor alpha (ESR1) and the more recently discovered estrogen receptor beta (ESR2). Genetic variation in genes involved in estrogen...

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Source

Identifiers

PMID: 16261413
DOI: 10.1007/s10549-005-7697-7

Genes

ESR2
ESR1

Variants

rs1256049
rs1256049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer.PMID 16261413Read ↗

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The estrogen receptor alpha C975G variant in familial and sporadic breast cancer: a case-control study.Semantic proximity Read ↗

Association of estrogen receptor-beta (ESR2) polymorphism and cancer risk: a meta-analysis.Semantic proximity Read ↗

ESR2 gene variants (rs1256049, rs4986938, and rs1256030) and their association with breast cancer risk.Semantic proximity Read ↗

Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women.Semantic proximity Read ↗

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