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Article

Role of microphthalmia transcription factor (Mitf) in melanoma differentiation.

Biochemical and biophysical research communications - 16 Mar 2007

Lekmine Fatima, Chang C K, Sethakorn Nan, Das Gupta Tapas K, Salti George I

Abstract excerpt

We transfected the melanocyte-specific Mitf-M isoform into the aggressive melanoma UISO-Mel-6 cell lines. Our data show that Mitf decreases cell proliferation and results in cells which grow in clusters. By analyzing the expression of the markers of differentiation, we demonstrate that Mitf favored increased expression of tyrosinase and tyrosinase-related protein-1. In addition, Mitf induces Bcl-2 expression...

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Source

Identifiers

PMID: 17266927
DOI: 10.1016/j.bbrc.2007.01.075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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