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FANCD2 functions as a critical factor downstream of MiTF to maintain the proliferation and survival of melanoma cells

9 Nov 2016

Abstract excerpt

Proteins involved in genetic stability maintenance and safeguarding DNA replication act not only against cancer initiation but could also play a major role in sustaining cancer progression. Here, we report that the FANC pathway is highly expressed in metastatic melanoma harboring the oncogenic microphthalmia-associated transcription factor (MiTF). We show that MiTF downregulation in melanoma cells lowers the...

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PMID: 27827420
DOI: 10.1038/srep36539

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