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Article

MicroRNA-26a inhibits the growth and invasiveness of malignant melanoma and directly targets on MITF gene

10 Jul 2017

Abstract excerpt

Abstract Metastatic melanoma is the most aggressive form of skin cancer and is refractory to therapy. MicroRNAs have been recently discovered as novel molecules that provide therapeutic benefits against melanoma. This work aims to examine the effects of miR-26a and let-7a on the growth and invasiveness of malignant melanomain vitroandin vivo. In addition, we elucidate the mechanism of action by identifying the...

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Identifiers

PMID: 28698805
DOI: 10.1038/cddiscovery.2017.28

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