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Article

Mitf dosage as a primary determinant of melanocyte survival after ultraviolet irradiation.

Pigment cell & melanoma research - 1 Jun 2009

Hornyak Thomas J, Jiang Shunlin, Guzmán Esther A, Scissors Beth N, Tuchinda Chinisada, He Hongbin, Neville James D, Strickland Faith M

Abstract excerpt

Microphthalmia-associated transcription factor (Mitf) is essential for melanocyte development and function and regulates anti-apoptotic Bcl2 expression. We hypothesized that cellular deficiency of Mitf can influence melanocyte survival in response to ultraviolet (UV) radiation. Primary melanocyte cultures were prepared from neonatal wild-type mice and congenic animals heterozygous for Mitf mutations Mitf...

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Identifiers

PMID: 19192212
DOI: 10.1111/j.1755-148X.2009.00551.x
PMCID: PMC6980044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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