Article
Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation.
Molecular nutrition & food research - 1 Feb 2007
Fisher Eva, Nitz Inke, Lindner Inka, Rubin Diana, Boeing Heiner, Möhlig Matthias, Hampe Jochen, Schreiber Stefan, Schrezenmeir Jürgen, Döring Frank
Abstract excerpt
To search for common variants etiological for type 2 diabetes, we screened 15 genes involved in fat assimilation for sequence variants. Approximately 55 kb in promoter and coding regions, and intron/splice sites were sequenced by cycle sequencing. In the set of 15 genes, 71 single nucleotide polymorphisms (SNPs) were detected. 33 SNPs were presumed to be functionally significant and were genotyped in 192 incident...
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