Article
Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals.
Molecular genetics and metabolism - 1 Dec 2009
Fisher Eva, Grallert Harald, Klapper Maja, Pfäfflin Albrecht, Schrezenmeir Jürgen, Illig Thomas, Boeing Heiner, Döring Frank
Abstract excerpt
The ileal fatty acid binding protein (FABP6) is known to be involved in enterohepatic bile acid metabolism. We have previously found a significant association between the rare allele of the FABP6 Thr79Met polymorphism and lower type 2 diabetes risk in a small case-control study (192 cases and 384 controls) embedded in the large EPIC-Potsdam cohort. A priori functional implication of the amino acid change was...
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