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Article

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.

PLoS biology - 1 Oct 2003

Barroso Inês, Luan Jian'an, Middelberg Rita P S, Harding Anne-Helen, Franks Paul W, Jakes Rupert W, Clayton D, Schafer Alan J, O'Rahilly Stephen, Wareham Nicholas J

Abstract excerpt

Type 2 diabetes is an increasingly common, serious metabolic disorder with a substantial inherited component. It is characterised by defects in both insulin secretion and action. Progress in identification of specific genetic variants predisposing to the disease has been limited. To complement ongoing positional cloning efforts, we have undertaken a large-scale candidate gene association study. We examined 152...

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Topics

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Share to Glucose Transporter Type 2
Share to Hepatocyte Nuclear Factor 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Secreting Cells

Share to Potassium Channels, Inwardly Rectifying

Share to Receptor, Insulin

Share to Receptors, Drug

Share to SOS1 Protein

Share to Sulfonylurea Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 14551916
DOI: 10.1371/journal.pbio.0000020
PMCID: PMC212698

Genes

ABCC8
INS
INSR
KCNJ11
SOS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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