The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function.

doi:10.1210/jc.2013-2378

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Article

The influence of rare genetic variation in SLC30A8 on diabetes incidence and β-cell function.

The Journal of clinical endocrinology and metabolism - 1 May 2014

Billings Liana K, Jablonski Kathleen A, Ackerman Rachel J, Taylor Andrew, Fanelli Rebecca R, McAteer Jarred B, Guiducci Candace, Delahanty Linda M, Dabelea Dana, Kahn Steven E, Franks Paul W, Hanson Robert L, Maruthur Nisa M, Shuldiner Alan R, Mayer-Davis Elizabeth J, Knowler William C, Florez Jose C

Abstract excerpt

CONTEXT/OBJECTIVE: The variant rs13266634 in SLC30A8, encoding a β-cell-specific zinc transporter, is associated with type 2 diabetes. We aimed to identify other variants in SLC30A8 that increase diabetes risk and impair β-cell function, and test whether zinc intake modifies this risk. DESIGN/OUTCOME: We sequenced exons in SLC30A8 in 380 Diabetes Prevention Program (DPP) participants and identified 44 novel...

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Identifiers

PMID: 24471563
DOI: 10.1210/jc.2013-2378
PMCID: PMC4010688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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