Article
A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
Journal of the American Society of Nephrology : JASN - 1 Jan 2007
Tchekneva Elena E, Rinchik Eugene M, Polosukhina Dina, Davis Linda S, Kadkina Veronika, Mohamed Yassir, Dunn Steve R, Sharma Kumar, Qi Zhonghua, Fogo Agnes B, Breyer Matthew D
Abstract excerpt
Diabetic nephropathy (DN) is a late diabetic complication that comprises progressively increasing albuminuria, declining GFR, and increased cardiovascular risk. Only a minority of patients with diabetes (25 to 40%) develop nephropathy, and there is evidence that heritable genetic factors predispose these "at-risk" individuals to DN. Comparing variability among inbred mouse strains with respect to a specific...
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