Article
Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development.
Acta diabetologica - 1 Jul 1998
Klöting I, Kovacs P
Abstract excerpt
Several crossing studies with diabetic BB rats have shown that in addition to the lymphopenia (Iddm1) and the MHC class II genes of the RT1U haplotype (Iddm2) there are further non-MHC genes essential for diabetes development. Because diabetes-resistant inbred rat strains may be homozygous for on...
Topics
- Age of Onset
- Animals
- Animals, Wild
- Diabetes Mellitus
- Female
- Genetic Predisposition to Disease
- Hybridization, Genetic
- Incidence
- Male
- Rats
- Rats, Inbred BB
- Sex Characteristics