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Article

Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development.

Acta diabetologica - 1 Jul 1998

Klöting I, Kovacs P

Abstract excerpt

Several crossing studies with diabetic BB rats have shown that in addition to the lymphopenia (Iddm1) and the MHC class II genes of the RT1U haplotype (Iddm2) there are further non-MHC genes essential for diabetes development. Because diabetes-resistant inbred rat strains may be homozygous for one of the diabetogenic non-MHC genes, masking the expression of diabetogenic genes and leading to an underestimation of...

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Identifiers

PMID: 9747965
DOI: 10.1007/s005920050114

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Research trail→

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Crosses between diabetic BB/OK and wild rats confirm that a third gene is essential for diabetes development.PMID 9747965Read ↗

Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.Semantic proximity Read ↗

Quantitative trait loci for blood glucose confirm diabetes predisposing and protective genes, Iddm4 and Iddm5r, in the spontaneously diabetic BB/OK rat.Semantic proximity Read ↗

Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus.Semantic proximity Read ↗

Influence of sex and phenotype of parents on the incidence of diabetes in BB/OK rat litters.Semantic proximity Read ↗

Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.Semantic proximity Read ↗

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.Semantic proximity Read ↗

Coat colour phenotype, leucopenia, and insulin-dependent diabetes mellitus (IDDM) in BB rats.Semantic proximity Read ↗

Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline.Semantic proximity Read ↗

Genes of the immune system cosegregate with the age at onset of diabetes in the BB/OK rat.Semantic proximity Read ↗

Phenotypic differences between diabetes-prone BB rat sublines cosegregate with loci on chromosomes X and 10.Semantic proximity Read ↗

Genetic variation in the multifunctional transcription factor Yy1 and type 1 diabetes mellitus in the BB rat.Semantic proximity Read ↗

Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility.Semantic proximity Read ↗

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