Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive compulsive-disorder.

Journal of psychopharmacology (Oxford, England) - 1 Nov 2007

Mössner Rainald, Döring Nicole, Scherag André, Schäfer Helmut, Herpertz-Dahlmann Beate, Remschmidt Helmut, Schulz Eberhard, Renner Tobias, Wewetzer Christoph, Warnke Andreas, Lesch Klaus-Peter, Walitza Susanne

Abstract excerpt

The 5-HT(3) receptor is unique among the serotonin receptors in that it is a ligand-gated ion channel. Dysfunction of the serotonin system is thought to contribute to the pathogenesis of obsessive-compulsive disorder (OCD). Apart from the standard treatment with serotonin reuptake inhibitors and behavioural therapy, a 5-HT(3) receptor antagonist has recently been shown to benefit some OCD patients, suggesting the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Age of Onset

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Genetic Variation

Share to Obsessive-Compulsive Disorder

Share to Receptors, Serotonin, 5-HT3

Source

Identifiers

PMID: 17259209
DOI: 10.1177/0269881106073560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transmission disequilibrium analysis of the functional 5-HT3A receptor variant C178T in early-onset obsessive compulsive-disorder.PMID 17259209Read ↗

Common variants of HTR3 genes are associated with obsessive-compulsive disorder and its phenotypic expression.Semantic proximity Read ↗

Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder.Semantic proximity Read ↗

Role of GAD2 and HTR1B genes in early-onset obsessive-compulsive disorder: results from transmission disequilibrium study.Semantic proximity Read ↗

5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study.Semantic proximity Read ↗

No association between obsessive-compulsive disorder and the 5-HT(1Dbeta) receptor gene.Semantic proximity Read ↗

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder.Semantic proximity Read ↗

5-HT2A promoter polymorphism -1438G/A in children and adolescents with obsessive-compulsive disorders.Semantic proximity Read ↗

Evidence for the gamma-amino-butyric acid type B receptor 1 (GABBR1) gene as a susceptibility factor in obsessive-compulsive disorder.Semantic proximity Read ↗

Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder.Semantic proximity Read ↗

Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder.Semantic proximity Read ↗

Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder.Semantic proximity Read ↗

Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.