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Article

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder.

The international journal of neuropsychopharmacology - 1 Aug 2006

Mössner Rainald, Walitza Susanne, Geller Frank, Scherag André, Gutknecht Lise, Jacob Christian, Bogusch Lisa, Remschmidt Helmut, Simons Michael, Herpertz-Dahlmann Beate, Fleischhaker Christian, Schulz Eberhard, Warnke Andreas, Hinney Anke, Wewetzer Christoph, Lesch Klaus-Peter

Abstract excerpt

Dysfunction of the central serotonergic system has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD). The genetic contribution to the development of OCD is particularly high in early-onset OCD. The aim of this study was to investigate the effect of polymorphic variants in the gene of the novel brain-specific tryptophan hydroxylase-2 (TPH2), the rate-limiting enzyme of serotonin (5-HT)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16146581
DOI: 10.1017/S1461145705005997

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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