Role of GAD2 and HTR1B genes in early-onset obsessive-compulsive disorder: results from transmission disequilibrium study.

doi:10.1111/gbb.12128

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Article

Role of GAD2 and HTR1B genes in early-onset obsessive-compulsive disorder: results from transmission disequilibrium study.

Genes, brain, and behavior - 1 Apr 2014

Mas S, Pagerols M, Gassó P, Ortiz A, Rodriguez N, Morer A, Plana M T, Lafuente A, Lazaro L

Abstract excerpt

One of the leading biological models of obsessive-compulsive disorder (OCD) is the frontal-striatal-thalamic model. This study undertakes an extensive exploration of the variability in genes related to the regulation of the frontal-striatal-thalamic system in a sample of early-onset OCD trios. To this end, we genotyped 266 single nucleotide polymorphisms (SNPs) in 35 genes in 84 OCD probands and their parents....

Topics

Adolescent
Age of Onset
Child
Female
Glutamate Decarboxylase
Haplotypes
Humans
Linkage Disequilibrium
Male
Obsessive-Compulsive Disorder
Polymorphism, Single Nucleotide
Receptor, Serotonin, 5-HT1B
Sex Factors

Source

Open in PubMed

Identifiers

PMID: 24571444
DOI: 10.1111/gbb.12128

Genes

GAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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