Article
Role of GAD2 and HTR1B genes in early-onset obsessive-compulsive disorder: results from transmission disequilibrium study.
Genes, brain, and behavior - 1 Apr 2014
Mas S, Pagerols M, Gassó P, Ortiz A, Rodriguez N, Morer A, Plana M T, Lafuente A, Lazaro L
Abstract excerpt
One of the leading biological models of obsessive-compulsive disorder (OCD) is the frontal-striatal-thalamic model. This study undertakes an extensive exploration of the variability in genes related to the regulation of the frontal-striatal-thalamic system in a sample of early-onset OCD trios. To this end, we genotyped 266 single nucleotide polymorphisms (SNPs) in 35 genes in 84 OCD probands and their parents....
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