Article
Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2003
Millet Bruno, Chabane Nadia, Delorme Richard, Leboyer Marion, Leroy Sophie, Poirier Marie-France, Bourdel Marie-Chantal, Mouren-Simeoni Marie-Christine, Rouillon Fréderic, Loo Henri, Krebs Marie-Odile
Abstract excerpt
Obsessive-compulsive disorder (OCD) is a frequent and disabling anxiety disorder. Dopamine (DA) might be involved in its pathophysiology, therefore DA receptors are candidate genes in OCD. A 48-base pairs (bp) polymorphism located in the third exon of the dopamine receptor type 4 (DRD4) gene has been described. Previous case control studies, however, have reported inconclusive results in OCD. The aim of the study...
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