Article
A plasminogen-activating protease specifically controls the development of primary pneumonic plague.
Science (New York, N.Y.) - 26 Jan 2007
Lathem Wyndham W, Price Paul A, Miller Virginia L, Goldman William E
Abstract excerpt
Primary pneumonic plague is transmitted easily, progresses rapidly, and causes high mortality, but the mechanisms by which Yersinia pestis overwhelms the lungs are largely unknown. We show that the plasminogen activator Pla is essential for Y. pestis to cause primary pneumonic plague but is less important for dissemination during pneumonic plague than during bubonic plague. Experiments manipulating its temporal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.