Article
Tn-Seq Analysis Identifies Genes Important for Yersinia pestis Adherence during Primary Pneumonic Plague.
mSphere - 5 Aug 2020
Eichelberger Kara R, Sepúlveda Victoria E, Ford John, Selitsky Sara R, Mieczkowski Piotr A, Parker Joel S, Goldman William E
Abstract excerpt
Following inhalation, Yersinia pestis rapidly colonizes the lung to establish infection during primary pneumonic plague. Although several adhesins have been identified in Yersinia spp., the factors mediating early Y. pestis adherence in the lung remain unknown. To identify genes important for Y. pestis adherence during primary pneumonic plague, we used transposon insertion sequencing (Tn-seq). Wild-type and...
Topics
- Animals
- Antigens, Bacterial
- Bacterial Adhesion
- Bacterial Proteins
- DNA Transposable Elements
- Disease Models, Animal
- Female
- Lung
- Mice
- Mice, Inbred C57BL
- Mutation