A surface protease and the invasive character of plague.

doi:10.1126/science.1439793

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Article

A surface protease and the invasive character of plague.

Science (New York, N.Y.) - 6 Nov 1992

Sodeinde O A, Subrahmanyam Y V, Stark K, Quan T, Bao Y, Goguen J D

Abstract excerpt

A 9.5-kilobase plasmid of Yersinia pestis, the causative agent of plague, is required for high virulence when mice are inoculated with the bacterium by subcutaneous injection. Inactivation of the plasmid gene pla, which encodes a surface protease, increased the median lethal dose of the bacteria...

Topics

Amino Acid Sequence
Animals
Bacterial Proteins
Colony Count, Microbial
Escherichia coli
Fibrinolysin
Injections, Intravenous
Kinetics
Liver
Mice
Molecular Sequence Data
Mutation
Plague
Plasmids
Plasminogen Activators
Recombinant Proteins
Spleen
Tissue Plasminogen Activator

Source

Open in PubMed

Identifiers

PMID: 1439793
DOI: 10.1126/science.1439793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1439793-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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