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Article

A surface protease and the invasive character of plague.

Science (New York, N.Y.) - 6 Nov 1992

Sodeinde O A, Subrahmanyam Y V, Stark K, Quan T, Bao Y, Goguen J D

Abstract excerpt

A 9.5-kilobase plasmid of Yersinia pestis, the causative agent of plague, is required for high virulence when mice are inoculated with the bacterium by subcutaneous injection. Inactivation of the plasmid gene pla, which encodes a surface protease, increased the median lethal dose of the bacteria for mice by a millionfold. Moreover, cloned pla was sufficient to restore segregants lacking the entire pla-bearing...

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Identifiers

PMID: 1439793
DOI: 10.1126/science.1439793

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