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Article

GM1 specifically interacts with alpha-synuclein and inhibits fibrillation.

Biochemistry - 20 Feb 2007

Martinez Zak, Zhu Min, Han Shubo, Fink Anthony L

Abstract excerpt

The aggregation of alpha-synuclein is believed to be a key step in the etiology of Parkinson's disease. Alpha-synuclein is found in the cytosol and is associated with membranes in the presynaptic region of neurons and has recently been reported to be associated with lipid rafts and caveolae. We examined the interactions between several brain sphingolipids and alpha-synuclein and found that alpha-synuclein...

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Identifiers

PMID: 17253773
DOI: 10.1021/bi061749a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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