Article
Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.
Journal of neuroscience research - 1 Apr 2007
Kanavouras Konstantinos, Mastorodemos Vasileios, Borompokas Nikolas, Spanaki Cleanthe, Plaitakis Andreas
Abstract excerpt
Glutamate dehydrogenase (GDH) is an enzyme central to the metabolism of glutamate that also plays a role in cellular energetics. In the human, GDH exists in a housekeeping isoenzyme (hGDH1) encoded by the GLUD1 gene and a neural and testicular tissue-specific isoform (hGDH2) encoded by the GLUD2 gene. There is evolutionary evidence that the GLUD1 was retroposed to the X chromosome in the ape ancestor (<23 million...
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