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Article

Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations.

The Biochemical journal - 1 Apr 2002

Fang Jie, Hsu Betty Y L, MacMullen Courtney M, Poncz Mortimer, Smith Thomas J, Stanley Charles A

Abstract excerpt

Glutamate dehydrogenase (GDH) catalyses the reversible oxidative deamination of l-glutamate to 2-oxoglutarate in the mitochondrial matrix. In mammals, this enzyme is highly regulated by allosteric effectors. The major allosteric activator and inhibitor are ADP and GTP, respectively; allosteric ac...

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Identifiers

PMID: 11903050
DOI: 10.1042/0264-6021:3630081
PMCID: PMC1222454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11903050-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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