Article

Structural Evolution of Primate Glutamate Dehydrogenase 2 as Revealed by in Silico Predictions and Experimentally Determined Structures

2023-05-30

Abstract excerpt

Glutamate dehydrogenase (GDH) interconverts glutamate to a-ketoglutarate and ammonia, interconnecting amino acid and carbohydrate metabolism. In humans, two functional GDH genes, GLUD1 and GLUD2, encode for hGDH1 and hGDH2, respectively. GLUD2 evolved from retro-transponsition of the GLUD1 gene in the common ancestor of modern apes. These two isoenzymes are involved in the pathophysiology of neoplastic, neurodegen...

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Literature Corpus work: 9aa55e71-344f-575c-871c-ec3cccc00f71
DOI: 10.20944/preprints202305.2133.v1

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