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Article

Deregulation of glutamate dehydrogenase in human neurologic disorders.

Journal of neuroscience research - 1 Aug 2013

Plaitakis Andreas, Zaganas Ioannis, Spanaki Cleanthe

Abstract excerpt

Mammalian glutamate dehydrogenase is an allosterically regulated enzyme that is central to glutamate metabolism. It contributes to important cellular processes, including Krebs cycle anaplerotic mechanisms, energy production, and ammonia homeostasis. In addition to this housekeeping hGDH1, humans have acquired through duplication an hGDH2 isoenzyme expressed in neural tissues with distinct regulatory properties....

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Source

Identifiers

PMID: 23463419
DOI: 10.1002/jnr.23176

Genes

GLUD1
GLUD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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