Article
The odyssey of a young gene: structure-function studies in human glutamate dehydrogenases reveal evolutionary-acquired complex allosteric regulation mechanisms.
Neurochemical research - 1 Jan 2014
Zaganas Ioannis V, Kanavouras Konstantinos, Borompokas Nikolas, Arianoglou Giovanna, Dimovasili Christina, Latsoudis Helen, Vlassi Metaxia, Mastorodemos Vasileios
Abstract excerpt
Mammalian glutamate dehydrogenase (GDH) catalyzes the reversible inter-conversion of glutamate to α-ketoglutarate and ammonia, interconnecting carbon skeleton and nitrogen metabolism. In addition, it functions as an energy switch by its ability to fuel the Krebs cycle depending on the energy status of the cell. As GDH lies at the intersection of several metabolic pathways, its activity is tightly regulated by...
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