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Article

Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology.

Journal of neurochemistry - 1 May 2021

Dimovasili Christina, Fadouloglou Vasiliki E, Kefala Aikaterini, Providaki Mary, Kotsifaki Dina, Kanavouras Konstantinos, Sarrou Iosifina, Plaitakis Andreas, Zaganas Ioannis, Kokkinidis Michael

Abstract excerpt

INTRODUCTION: Mammalian glutamate dehydrogenase (hGDH1 in human cells) interconverts glutamate to α-ketoglutarate and ammonia while reducing NAD(P) to NAD(P)H. During primate evolution, humans and great apes have acquired hGDH2, an isoenzyme that underwent rapid evolutionary adaptation concomitantly with brain expansion, thereby acquiring unique catalytic and regulatory properties that permitted its function...

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PMID: 33421122
DOI: 10.1111/jnc.15296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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