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Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development

26 Apr 2016

Abstract excerpt

Whereas all mammals have one glutamate dehydrogenase gene (GLUD1), humans and apes carry an additional gene (GLUD2), which encodes an enzyme with distinct biochemical properties. We inserted a bacterial artificial chromosome containing the human GLUD2 gene into mice and analyzed the resulting changes in the transcriptome and metabolome during postnatal brain development. Effects were most pronounced early...

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PMID: 27118840
DOI: 10.1073/pnas.1519261113

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