Article
A novel mannose-binding lectin-associated serine protease 1/3 gene variant.
Scandinavian journal of immunology - 1 May 2007
Weiss G, Madsen H O, Garred P
Abstract excerpt
The ficolins and mannose-binding lectin (MBL) create complexes with three different serine proteases (MASP-1, MASP-2 and MASP-3) and a truncated non-enzymatic form of MASP-2 (sMAP). MASP-2 is able to activate complement by cleavage of C4 and C2, while the physiological functions of MASP-1, MASP-3 and sMAP still are debated. MASP-1 and MASP-3 are alternative spliced forms of the same MASP gene. To gain insight in...
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