Article
Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2007
Kritz Angelika B, Nicol Campbell G, Dishart Kate L, Nelson Ruth, Holbeck Susan, Von Seggern Dan J, Work Lorraine M, McVey John H, Nicklin Stuart A, Baker Andrew H
Abstract excerpt
Adenoviral vectors are commonly used for liver-directed gene therapy following systemic administration owing to their strong propensity for hepatocyte transduction. However, many disease applications would benefit from the delivery of adenoviruses to alternate tissues via this route. Research has thus focused on stripping the virus of native hepatic tropism in conjunction with modifying virus capsid proteins to...
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