Article
Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism.
Gene therapy - 1 Jan 2001
Leissner P, Legrand V, Schlesinger Y, Hadji D A, van Raaij M, Cusack S, Pavirani A, Mehtali M
Abstract excerpt
Targeting of adenovirus (Ad)-encoded therapeutic genes to specific cell types has become a major goal in gene therapy. Redirecting the specificity of infection requires the abrogation of the natural interaction between the viral fiber and its cellular receptors (CAR) and the simultaneous introduction of a new binding specificity into the viral capsid. To abrogate the natural affinity of the fiber, we have mutated...
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