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Article

Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2004

Nicol Campbell G, Graham Delyth, Miller William H, White Stephen J, Smith Theodore A G, Nicklin Stuart A, Stevenson Susan C, Baker Andrew H

Abstract excerpt

Sequestration of adenovirus serotype 5 (Ad5) in liver restricts its use for gene delivery to other target sites in vivo. To date, no studies have systematically assessed the impact of genetic capsid modifications on in vivo tropism in rats, an important preclinical model for many disease types. We evaluated a panel of Ad5 vectors with capsid mutations or pseudotyped with the short fiber from serotype 41 (Ad41s)...

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Share to Adenoviridae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutination

Share to Heparan Sulfate Proteoglycans

Share to Hepatocytes

Share to Rats, Inbred WKY

Share to Receptors, Virus

Share to Transduction, Genetic

Source

Identifiers

PMID: 15294181
DOI: 10.1016/j.ymthe.2004.05.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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