Article
In vivo hepatic adenoviral gene delivery occurs independently of the coxsackievirus-adenovirus receptor.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jun 2002
Smith Theodore, Idamakanti Neeraja, Kylefjord Helen, Rollence Michele, King Laura, Kaloss Michele, Kaleko Michael, Stevenson Susan C
Abstract excerpt
Systemic administration of adenoviral vectors leads to a widespread distribution of vector. Therefore, targeting of adenoviral vectors to specific tissues or cell types will require methods to ablate the normal tropism of the vector simultaneously with the introduction of new receptor specificities. To inhibit native receptor binding, we mutated residues in the AB loop of the adenovirus type 5 (Ad5) fiber. We...
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