Article
Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo.
Human gene therapy - 1 Nov 2004
Denby Laura, Work Lorraine M, Graham Delyth, Hsu Catherine, von Seggern Dan J, Nicklin Stuart A, Baker Andrew H
Abstract excerpt
Adenovirus (Ad5) serotype 5 vectors are commonly used for gene transfer. Preclinical studies have shown that their application to systemic gene delivery, however, is limited by their highly efficient uptake in the liver, principally mediated by receptor-binding sites on the fiber shaft and knob domain. Using Ad to target other sites in vivo requires vectors that lack hepatic tropism. We therefore sought to...
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