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Article

Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie B-adenovirus receptor-bearing cells.

Journal of virology - 1 Mar 2001

Jakubczak J L, Rollence M L, Stewart D A, Jafari J D, Von Seggern D J, Nemerow G R, Stevenson S C, Hallenbeck P L

Abstract excerpt

A major limitation of adenovirus type 5 (Ad5)-based gene therapy, the inability to target therapeutic genes to selected cell types, is attributable to the natural tropism of the virus for the widely expressed coxsackievirus-adenovirus receptor (CAR) protein. Modifications of the Ad5 fiber knob domain have been shown to alter the tropism of the virus. We have developed a novel system to rapidly evaluate the...

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Identifiers

PMID: 11222722
DOI: 10.1128/JVI.75.6.2972-2981.2001
PMCID: PMC115923

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Source receipt: pubmed, retrieved 7 Sept 2026.

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