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Article

Simultaneous CAR- and alpha V integrin-binding ablation fails to reduce Ad5 liver tropism.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2003

Martin Karine, Brie Anne, Saulnier Patrick, Perricaudet Michel, Yeh Patrice, Vigne Emmanuelle

Abstract excerpt

Targeting adenovirus encoding therapeutic genes to specific cell types has become a major goal in gene therapy. Coxsackievirus and adenovirus receptor (CAR) and alpha(V) integrins have been identified as the primary cell surface components that interact with adenovirus type 5 (Ad5)-based vectors...

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Identifiers

PMID: 12946322
DOI: 10.1016/s1525-0016(03)00182-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12946322-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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