Article
Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice.
Human gene therapy - 20 May 2003
Smith Theodore A G, Idamakanti Neeraja, Rollence Michele L, Marshall-Neff Jennifer, Kim Jin, Mulgrew Kathy, Nemerow Glen R, Kaleko Michael, Stevenson Susan C
Abstract excerpt
Adenoviral vectors used in gene therapy are predominantly derived from adenovirus serotype 5 (Ad5), which infects a broad range of cells. Ad5 cell entry involves interactions with the coxsackie-adenovirus receptor (CAR) and integrins. To assess these receptors in vivo, we mutated amino acid residues in fiber and penton that are involved in receptor interaction and showed that CAR and integrins play a minor role...
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