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Article

Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice.

Human gene therapy - 20 May 2003

Smith Theodore A G, Idamakanti Neeraja, Rollence Michele L, Marshall-Neff Jennifer, Kim Jin, Mulgrew Kathy, Nemerow Glen R, Kaleko Michael, Stevenson Susan C

Abstract excerpt

Adenoviral vectors used in gene therapy are predominantly derived from adenovirus serotype 5 (Ad5), which infects a broad range of cells. Ad5 cell entry involves interactions with the coxsackie-adenovirus receptor (CAR) and integrins. To assess these receptors in vivo, we mutated amino acid resid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12804140
DOI: 10.1089/104303403765255165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12804140-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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