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Rabbit somatic cell cloning: effects of donor cell type, histone acetylation status and chimeric embryo complementation

1 Jan 2007

Abstract excerpt

The epigenetic status of a donor nucleus has an important effect on the developmental potential of embryos produced by somatic cell nuclear transfer (SCNT). In this study, we transferred cultured rabbit cumulus cells (RCC) and fetal fibroblasts (RFF) from genetically marked rabbits (Alicia/Basilea) into metaphase II oocytes and analyzed the levels of histone H3-lysine 9-lysine 14 acetylation (acH3K9/14) in donor...

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PMID: 17244748
DOI: 10.1530/rep.1.01206

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