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BIX-01294 increases pig cloning efficiency by improving epigenetic reprogramming of somatic cell nuclei

25 Nov 2015

Abstract excerpt

Accumulating evidence suggests that faulty epigenetic reprogramming leads to the abnormal development of cloned embryos and results in the low success rates observed in all mammals produced through somatic cell nuclear transfer (SCNT). The aberrant methylation status of H3K9me and H3K9me2 has been reported in cloned mouse embryos. To explore the role of H3K9me2 and H3K9me in the porcine somatic cell nuclear...

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PMID: 26604326
DOI: 10.1530/rep-15-0460

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