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Trichostatin A Improves Histone Acetylation in Bovine Somatic Cell Nuclear Transfer Early Embryos

17 Apr 2008

Abstract excerpt

Epigenetic aberrancies likely preclude correct and complete nuclear reprogramming following somatic cell nuclear transfer (SCNT), and may underlie the observed reduced viability of cloned embryos. In the present study, we tested the effects of the histone deacetylase inhibitor (HDACi), trichostatin A (TSA), on development and histone acetylation of cloned bovine preimplantation embryos. Our results indicated that...

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PMID: 18419249
DOI: 10.1089/clo.2007.0002

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Related research

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Trichostatin A Improves Histone Acetylation in Bovine Somatic Cell Nuclear Transfer Early EmbryosPMID 18419249Read ↗

Trichostatin A Promotes the Development of Bovine Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errorsSemantic proximity Read ↗

Trichostatin A Improved Epigenetic Modifications of Transfected Cells but did not Improve Subsequent Cloned Embryo DevelopmentSemantic proximity Read ↗

Acetylation Level of Histone H3 in Early Embryonic Stages Affects Subsequent Development of Miniature Pig Somatic Cell Nuclear Transfer EmbryosSemantic proximity Read ↗

Trichostatin A and nuclear reprogramming of cloned rabbit embryos1Semantic proximity Read ↗

Trichostatin A Modulates Apoptotic-Related Gene Expression and Improves Embryo Viability in Cloned Bovine EmbryosSemantic proximity Read ↗

The Effects of Trichostatin A on mRNA Expression of Chromatin Structure-, DNA Methylation-, and Development-Related Genes in Cloned Mouse BlastocystsSemantic proximity Read ↗

Trichostatin A specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transferSemantic proximity Read ↗

Treatment of Nuclear-Donor Cells or Cloned Zygotes with Chromatin-Modifying Agents Increases Histone Acetylation But Does Not Improve Full-Term Development of Cloned CattleSemantic proximity Read ↗

The Effects of 5-Aza-2′- Deoxycytidine and Trichostatin A on Gene Expression and DNA Methylation Status in Cloned Bovine BlastocystsSemantic proximity Read ↗

Histone Deacetylase Inhibitors Improve <i>In Vitro</i> and <i>In Vivo</i> Developmental Competence of Somatic Cell Nuclear Transfer Porcine EmbryosSemantic proximity Read ↗

Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryosSemantic proximity Read ↗

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