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Multiple histone site epigenetic modifications in nuclear transfer and<i>in vitro</i>fertilized bovine embryos

8 Jul 2010

Abstract excerpt

During mammalian embryonic development, DNA methylation and histone modifications are important in gene expression regulation and epigenetic reprogramming. In cloned embryos, high levels of DNA methylation and abnormal demethylation were widely observed during the preimplantation period. Little is known whether there is a difference in histone modifications between in vitro fertilization (IVF) and cloned embryos...

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PMID: 20609268
DOI: 10.1017/s0967199410000328

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