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Article

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.

The Journal of biological chemistry - 16 Mar 2007

Wang Yamin, Singh Usha, Mueller David M

Abstract excerpt

The mitochondrial ATP synthase is a molecular motor, which couples the flow of protons with phosphorylation of ADP. Rotation of the central stalk within the core of ATP synthase effects conformational changes in the active sites driving the synthesis of ATP. Mitochondrial genome integrity (mgi) mutations have been previously identified in the alpha-, beta-, and gamma-subunits of ATP synthase in yeast...

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Identifiers

PMID: 17244612
DOI: 10.1074/jbc.M609635200
PMCID: PMC3670140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.PMID 17244612Read ↗

Crystal structures of mutant forms of the yeast F1 ATPase reveal two modes of uncoupling.Semantic proximity Read ↗

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The mitochondrial genome integrity gene, MGI1, of Kluyveromyces lactis encodes the beta-subunit of F1-ATPase.Semantic proximity Read ↗

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A "petite obligate" mutant of Saccharomyces cerevisiae: functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase.Semantic proximity Read ↗

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