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A "petite obligate" mutant of Saccharomyces cerevisiae: functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase.

The Journal of biological chemistry - 16 Jun 2006

Duvezin-Caubet Stéphane, Rak Malgorzata, Lefebvre-Legendre Linnka, Tetaud Emmanuel, Bonnefoy Nathalie, di Rago Jean-Paul

Abstract excerpt

Within the mitochondrial F(1)F(0)-ATP synthase, the nucleus-encoded delta-F(1) subunit plays a critical role in coupling the enzyme proton translocating and ATP synthesis activities. In Saccharomyces cerevisiae, deletion of the delta subunit gene (Deltadelta) was shown to result in a massive destabilization of the mitochondrial genome (mitochondrial DNA; mtDNA) in the form of 100% rho(-)/rho degrees petites (i.e....

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PMID: 16608846
DOI: 10.1074/jbc.M513805200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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