Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant residues suppressing rho(0)-lethality in Kluyveromyces lactis occur at contact sites between subunits of F(1)-ATPase.

Biochimica et biophysica acta - 16 Mar 2000

Clark-Walker G D, Hansbro P M, Gibson F, Chen X J

Abstract excerpt

Characterisation of 35 Kluyveromyces lactis strains lacking mitochondrial DNA has shown that mutations suppressing rho(0)-lethality are limited to the ATP1, 2 and 3 genes coding for the alpha-, beta- and gamma- subunits of mitochondrial F(1)-ATPase. All atp mutations reduce growth on glucose and three alleles, atp1-2, 1-3 and atp3-1, produce a respiratory deficient phenotype that indicates a drop in efficiency of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Crystallography
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Suppressor

Share to Kluyveromyces

Share to Mitochondria

Share to Models, Molecular

Share to Proton-Translocating ATPases

Source

Identifiers

PMID: 10719181
DOI: 10.1016/s0167-4838(00)00003-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant residues suppressing rho(0)-lethality in Kluyveromyces lactis occur at contact sites between subunits of F(1)-ATPase.PMID 10719181Read ↗

Suppression of rho0 lethality by mitochondrial ATP synthase F1 mutations in Kluyveromyces lactis occurs in the absence of F0.Semantic proximity Read ↗

Dual mutations reveal interactions between components of oxidative phosphorylation in Kluyveromyces lactis.Semantic proximity Read ↗

The F1-ATPase inhibitor Inh1 (IF1) affects suppression of mtDNA loss-lethality in Kluyveromyces lactis.Semantic proximity Read ↗

Mutations on the N-terminal edge of the DELSEED loop in either the α or β subunit of the mitochondrial F1-ATPase enhance ATP hydrolysis in the absence of the central γ rotor.Semantic proximity Read ↗

Allele-specific expression of the Mgi- phenotype on disruption of the F1-ATPase delta-subunit gene in Kluyveromyces lactis.Semantic proximity Read ↗

Absence of F1-ATPase activity in Kluyveromyces lactis lacking the epsilon subunit.Semantic proximity Read ↗

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.Semantic proximity Read ↗

The mitochondrial genome integrity gene, MGI1, of Kluyveromyces lactis encodes the beta-subunit of F1-ATPase.Semantic proximity Read ↗

Specific mutations in alpha- and gamma-subunits of F1-ATPase affect mitochondrial genome integrity in the petite-negative yeast Kluyveromyces lactis.Semantic proximity Read ↗

A "petite obligate" mutant of Saccharomyces cerevisiae: functional mtDNA is lethal in cells lacking the delta subunit of mitochondrial F1-ATPase.Semantic proximity Read ↗

Structure, functioning, and assembly of the ATP synthase in cells from patients with the T8993G mitochondrial DNA mutation. Comparison with the enzyme in Rho(0) cells completely lacking mtdna.Semantic proximity Read ↗

Alpha and beta subunits of F1-ATPase are required for survival of petite mutants in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.