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Article

Crystal structures of mutant forms of the yeast F1 ATPase reveal two modes of uncoupling.

The Journal of biological chemistry - 19 Nov 2010

Arsenieva Diana, Symersky Jindrich, Wang Yamin, Pagadala Vijayakanth, Mueller David M

Abstract excerpt

The mitochondrial ATP synthase couples the flow of protons with the phosphorylation of ADP. A class of mutations, the mitochondrial genome integrity (mgi) mutations, has been shown to uncouple this process in the yeast mitochondrial ATP synthase. Four mutant forms of the yeast F(1) ATPase with mgi mutations were crystallized; the structures were solved and analyzed. The analysis identifies two mechanisms of...

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Identifiers

PMID: 20843806
DOI: 10.1074/jbc.M110.174383
PMCID: PMC2978584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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