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Article

A vital function for mitochondrial DNA in the petite-negative yeast Kluyveromyces lactis.

Molecular & general genetics : MGG - 28 Oct 1996

Clark-Walker G D, Chen X J

Abstract excerpt

Petite-negative yeasts do not form viable respiratory-deficient mutants on treatment with DNA-targeting drugs that readily eliminate the mitochondrial DNA (mtDNA) from petite-positive yeasts. However, in the petite-negative yeast Kluyveromyces lactis, specific mutations in the nuclear genes MG12 and MG15 encoding the alpha- and gamma-subunits of the mitochondrial F1-ATPase, allow mtDNA to be lost. In this study...

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Identifiers

PMID: 8917319
DOI: 10.1007/BF02173982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A vital function for mitochondrial DNA in the petite-negative yeast Kluyveromyces lactis.PMID 8917319Read ↗

Specific mutations in alpha- and gamma-subunits of F1-ATPase affect mitochondrial genome integrity in the petite-negative yeast Kluyveromyces lactis.Semantic proximity Read ↗

Mutations in MGI genes convert Kluyveromyces lactis into a petite-positive yeast.Semantic proximity Read ↗

Allele-specific expression of the Mgi- phenotype on disruption of the F1-ATPase delta-subunit gene in Kluyveromyces lactis.Semantic proximity Read ↗

The mitochondrial genome integrity gene, MGI1, of Kluyveromyces lactis encodes the beta-subunit of F1-ATPase.Semantic proximity Read ↗

Suppression of rho0 lethality by mitochondrial ATP synthase F1 mutations in Kluyveromyces lactis occurs in the absence of F0.Semantic proximity Read ↗

Mitochondrial ATP synthase subunit 9 is not required for viability of the petite-negative yeast Kluyveromyces lactis.Semantic proximity Read ↗

Expression of the Saccharomyces cerevisiae gene YME1 in the petite-negative yeast Schizosaccharomyces pombe converts it to petite-positive.Semantic proximity Read ↗

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.Semantic proximity Read ↗

The petite mutation in yeasts: 50 years on.Semantic proximity Read ↗

Absence of F1-ATPase activity in Kluyveromyces lactis lacking the epsilon subunit.Semantic proximity Read ↗

Alpha and beta subunits of F1-ATPase are required for survival of petite mutants in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ability for anaerobic growth is not sufficient for development of the petite phenotype in Saccharomyces kluyveri.Semantic proximity Read ↗

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