Specific mutations in alpha- and gamma-subunits of F1-ATPase affect mitochondrial genome integrity in the petite-negative yeast Kluyveromyces lactis.

doi:10.1002/j.1460-2075.1995.tb07331.x

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Article

Specific mutations in alpha- and gamma-subunits of F1-ATPase affect mitochondrial genome integrity in the petite-negative yeast Kluyveromyces lactis.

The EMBO journal - 3 Jul 1995

Chen X J, Clark-Walker G D

Abstract excerpt

We have shown previously that mutations in nuclear genes, termed MGI, for mitochondrial genome integrity, can convert the petite-negative yeast Kluyveromyces lactis into a petite-positive form with the ability to produce mitochondrial genome deletion mutants (Chen and Clark-Walker, Genetics, 133, 517-525, 1993). Here we describe that two genes, MGI2 and MGI5, encode the alpha- and gamma-subunits of mitochondrial...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cattle
DNA, Mitochondrial
Escherichia coli
Ethidium
Gene Deletion
Gene Expression Regulation, Fungal
Genes, Fungal
Kluyveromyces

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mitochondria

Molecular Sequence Data

Phenotype

Point Mutation

Protein Conformation

Proton-Translocating ATPases

Saccharomyces cerevisiae

Source

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Identifiers

PMID: 7621839
DOI: 10.1002/j.1460-2075.1995.tb07331.x
PMCID: PMC394390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7621839-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Specific mutations in alpha- and gamma-subunits of F1-ATPase affect mitochondrial genome integrity in the petite-negative yeast Kluyveromyces lactis.PMID 7621839Read ↗

The mitochondrial genome integrity gene, MGI1, of Kluyveromyces lactis encodes the beta-subunit of F1-ATPase.Semantic proximity Read ↗

A vital function for mitochondrial DNA in the petite-negative yeast Kluyveromyces lactis.Semantic proximity Read ↗

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Mutations in MGI genes convert Kluyveromyces lactis into a petite-positive yeast.Semantic proximity Read ↗

Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase.Semantic proximity Read ↗

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Alpha and beta subunits of F1-ATPase are required for survival of petite mutants in Saccharomyces cerevisiae.Semantic proximity Read ↗

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