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Article

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

The Journal of clinical investigation - 1 Jun 2003

Siegfried Geraldine, Basak Ajoy, Cromlish James A, Benjannet Suzanne, Marcinkiewicz Jadwiga, Chrétien Michel, Seidah Nabil G, Khatib Abdel-Majid

Abstract excerpt

The secretory factor VEGF-C has been directly implicated in various physiological processes during embryogenesis and human cancers. However, the importance of the conversion of its precursor proVEGF-C to mature VEGF-C in tumorigenesis, and vessel formation and the identity of the protease(s) that regulate these processes is/are not known. The intracellular processing of proVEGF-C that occurs within the dibasic...

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Identifiers

PMID: 12782675
DOI: 10.1172/JCI17220
PMCID: PMC156106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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