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Article

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

8 May 2016

Abstract excerpt

Lymphangiogenesis is supported by 2 homologous VEGFR3 ligands, VEGFC and VEGFD. VEGFC is required for lymphatic development, while VEGFD is not. VEGFC and VEGFD are proteolytically cleaved after cell secretion in vitro, and recent studies have implicated the protease a disintegrin and metalloproteinase with thrombospondin motifs 3 (ADAMTS3) and the secreted factor collagen and calcium binding EGF domains 1...

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PMID: 27159393
DOI: 10.1172/jci83967

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